Effects of TRH-tartrate on Anterior Pituitary Hormone Release in Men
1976 Volume 7 Issue 2 Pages 135-143
Details
1976 Volume 7 Issue 2 Pages 135-143
The effects of TRH-tartrate (TRH-T), a synthetic TRH analogue, on anterior pituitary hormone release were investigated in 10 normal male adults. In addition, the physical and laboratory findings were examined before and after TRH-T administration to check its side effects.
The intravenous administration of 500μg TRH-T stimulated TSH secretionfollowed by the increase of thyroid hormone (T3 and T4) release in all subjects. The peak levels of plasma TSH were observed between 15 and 30 min after the injec tion with the values of 12.5±1.48μU/ml
Plasma prolactin levels reached to the maximum (12.7±1.72 ng/ml) about 15 min earlier than TSH peak levels.
Plasma GH and LH levels in response to TRH-T were increased in some cases and plasma FSH and cortisol did not show any significant changes after the injection.
No significant side effects were observed in view of physical and laboratory findings in all subjects who were examined before and after TRH-T administration.
These results indicate that TRH-T is a useful tool for testing pituitary reserves of TSH and prolactin, since it posesses a stimulating effect on the hormone release without any significant side effects.
