Strategies in chemical genetics

Abstract

The use of small molecule for perturbing protein function have potential advantages to classic genetics, while genetics is still valuable in complementing disadvantages of small molecule approach. Although the theoretical framework of small molecule-approach have been established, practical aspect of this strategy still needs more examples to be discussed. Here, I discuss some practices from our current work related to small molecules, as with an attempt to show what experiments should be prioritized for small molecule approach.