Cytomegalovirus infection after kidney transplantation

─ Focused on GCV resistant mutants and prophylaxis ─

Abstract

CMV infection is one of the most important morbidity after kidney transplantation. Recent advancement of diagnostic tool such as CMV Ag method and PCR, and/or GCV/VGCV production and clinical application served early diagnosis and effective treatment, however, several refractory organ/tissue invasive disease caused by GCV resistant CMV mutants have been reported elsewhere in Japan and worldwide. In this article, I would like to review the up to dated diagnosis, treatment and prophylaxis guidelines and introduce the results from our multicenter research on the early diagnosis of the GCV resistant CMV mutants supported by the grant from Japan Society of Clinical Renal Transplantation.