Thermodynamic Analyses of Antibody-Antigen Interactions : Specificity and Affinity

Abstract

Antibodies are widely used for various fields, including identification of targets, molecular imaging, diagnosis, and therapeutics. Fundamental understanding of interactions from thermodynamic viewpoints, based on structural information, is critical for rational design of antigen-specificity and affinity of antibody. Here, we would summarize our recent progresses on thermodynamic analyses of antibody-antigen interactions, and review the molecular mechanism for how an antibody can create the high specificity and affinity for its target, especially form thermodynamic and structural viewpoints.