Abstract
Molecular conformation/arrangement of active pharmaceutical ingredients and excipients in the solid state has great impact on physicochemical characteristics of the formulations including solubility and stability. Although various methodologies are available for their investigation, thermal analysis has great advantages in terms of its high sensitivity and flexibility. In this paper, thermal analysis for the evaluation of polymorphism and amorphous state is described from practical viewpoint in the pharmaceutical industry.
https://ror.org/026v1ze26 
