Abstract
For thermoanalysis-based stability prediction of a drug candidate, the highest temperature applicable so far to humidity-controlling of gas flow into a heat furnace has been limited to about 80℃. We solved this limitation by placing a water-containing bottle between gas-flow tubing segments and then flowing a humidity-saturated nitrogen gas at room temperature into the heat furnace to decompose a sample. This allowed furnace-heating at 150℃. In this study, the predicted decomposition rate was compatible with the actual decomposition rate, but it would be necessary to validate this method in future.
