Abstract
Chemical substances and the chemical processes that handle them inherently have energy potential. Therefore, for
safe and efficient operation and management, it is necessary to appropriately evaluate the hazards of these substances and processes, and to implement risk management appropriately to the purpose based on the results. Measuring the amount of heat generated during the reaction and its time change is meaningful for evaluating the hazards of these chemical substances and processes, and the use of calorimetry techniques is effective for obtaining this information. This paper presents examples of serious accidents that have occurred in chemical reaction systems in the past and their causes, and introduces hazard/risk evaluation methods for the safe operation of chemical substances and processes, as well as their effectiveness and application.