Abstract
This review demonstrated the possibility of application of isothermal microcalorimetry (IMC) for stability evaluation of solid dosage form. Various kinetic equations derived from the different reaction model in the solid state were applied for the obtained data using isothermal microcalorimeter. Suitable decomposition rate constant was successfully derived from the most appropriate kinetic equation evaluated by curve fitting method. Experimental decomposition rate constant of solid dosage form was determined by the time-consuming conventional method, which took more than 6 months. The predicted values were in good agreement with the experimental values. By using this method, the stability of solid dosage form can be predicted by a simple operation in a short time. Application of IMC would be useful for the screening test for the drug stability.
