Abstract
Antimicrobial activities were investigated using a calorimeter capable of measuring the heat evolved when soil microbes multiplied in the soil. The peak of heat evolution due to microbial growth with metabolic degradation of glucose in the soil shifted toward a longer incubation as the concentration of antimicrobial agent in soil increased. Their values of MIC (minimum inhibitory concentration) for the antimicrobial activities were determined using the non-competitive inhibition kinetic model proposed by Takahashi et al. Antifungal activities of TBZ (2-(4'-Thiazolyl)-benzimidazole) against Aspergillus niger were evaluated by this method.
