A case of drug-induced rhabdomyolysis in intracardiac repair for a ventricular septal defect

Abstract

　We encountered an 11-year-old male patient who presented with rhabdomyolysis after intracardiac repair for a ventricular septal defect.

　We considered the administration of propofol in the intraoperative period as the cause of rhabdomyolysis because a correlation was noted between creatine kinase and acylcarnitine, indicating a disturbance in fatty acid oxidation in the postoperative period. The mechanism responsible for rhabdomyolysis may be an energy supply imbalance caused by the combination of a disturbance in fatty acid oxidation and increased demand for fatty acid oxidation with cardiopulmonary bypass.

　We used propofol only in the intraoperative period, and the patient was discharged without organ failure.