The Japanese Journal of Dysphagia Rehabilitation
Online ISSN : 2434-2254
Print ISSN : 1343-8441
Short Communication
Tablet Size of Magnesium Oxide Tablets Affects Disintegration Time and Dissolution Rate with Swallowing Auxiliary Products
Taisuke MATSUOKenzo KUDO
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2024 Volume 28 Issue 1 Pages 37-42

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Abstract

 Swallowing auxiliary products are useful for people with aphagia to enable them to drink, eat, and take their medicines. However, inappropriate usage of the products causes disintegration-delay and non-disintegration of the tablets, reducing drug efficacy. Sometimes, magnesium oxide tablets used as an antacid or laxative are taken with the help of swallowing auxiliary products. Detection of a non-disintegrated tablet in the stool of a patient who took the tablet using a thickening agent has been reported. In this study, we investigated how immersion of magnesium oxide tablets of various sizes (diameter: 7.5 mm, 8 mm, 9 mm, 10.5 mm) with three different swallowing auxiliary products (xanthan gum, guar gum food thickener, and swallowing aid jelly) affected their disintegration and dissolution. In the xanthan gum food thickener and swallowing aid jelly, the disintegration time of the tablets was similar to that of non-immersed tablets. In the guar gum food thickener, the disintegration time of the tablets (7.5 and 8 mm) was longer than that of the other tablets. The most significant effect was observed in the 7.5-mm tablets, and the dissolution rate was the lowest. Thus, the results showed that small-size magnesium oxide tablets are easily affected by guar gum food thickeners.

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© 2024 The Japanese Society of Dysphagia Rehabilitation
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