Abstract
Objectives: Hemodialysis patients are at risk of malnutrition, inflammation, and atherosclerosis, which make up MIA syndrome. Here, we assessed the geriatric nutritional risk indexes (GNRI) of patients undergoing maintenance dialysis, then measured various parameters such as serum CPR, plasma IL-6, Fetuin-A, and 8-OHdG to investigate the nutritional status, and investigated correlations between these. Subjects: One hundred and thirty-eight patients were undergoing stable maintenance hemodialysis at this institution. Of these, 95 were men and 43 women. The mean age was 69±11 years (38 to 88 years), and the mean dialysis time was 58±60 months (3 to 390 months). Methods: GNRI was that proposed by Bouillanne et al., calculated using a formula revised by Yamada et al. Plasma IL-6, Fetuin-A, and 8-OHdG were assessed with enzyme-linked immunosorbent assay (ELISA) methods. Results: GNRI slowly decreased with advancing age, and a significant negative correlation with age was shown. Moreover, significantly lower values were shown for women compared to men, while significant differences with or without diabetic nephropathy as an underlying disease were not noted. In terms of the biochemical parameters, positive correlations were shown for serum albumin (p<0.0001) and Fetuin-A (p<0.01), while negative correlations were shown for CRP (p<0.0005), IL-6 (p<0.0001), and 8-OHdG (p<0.0001). Results: We believe the GNRI to be an easily measureable guide reflecting the nutritional status of dialysis patients. Moreover, it was suggested that there are close relationships between the GNRI and nutrition, inflammation, atherosclerosis, and oxidative stress.
