Abstract
Maintenance of an appropriate body fluid volume in hemodialysis patients is important for reduction of the risk of CVD events and improvement of prognosis. We evaluated overhydration (OH) in healthy controls and hemodialysis (HD) patients using a bioimpedance spectroscopy device cross-sectionally. In the present study, 219 healthy controls (mean age 68.8±8.4 years, 69 men) and 64 HD patients (61.7±12.8 years, 37 men) were enrolled. The average OH of healthy controls was 0.70±0.78 L, and 76.3% of them were within the healthy reference range (−1.1-1.1 L). Before and after HD, OH was 2.9±1.5 L and 0.6±1.7 L, respectively. The amount of ultrafiltration was significantly correlated with the absolute change of OH before and after HD (r=0.61, p<0.05). Before and after HD, OH was not significantly associated with blood pressure or cardiothoracic ratio before HD. After HD, OH was significantly associated with ANP level after HD (r=0.48, p<0.05). Patients with HD were divided into 3 groups based on ANP level after HD (higher>60 pg/mL, median 40-60 pg/mL, lower<40 pg/mL) ; mean OH after HD was significantly different (p<0.05). In conclusion, these data suggest that a bioimpedance spectroscopy device could be useful to evaluate fluid status in patients with HD. We need to perform further studies to assess the relationship between OH and cardiac function. We also need to investigate the usefulness of OH in terms of evaluating over-volume regardless of cardiac function and predicted survival.
