Nihon Toseki Igakkai Zasshi
Online ISSN : 1883-082X
Print ISSN : 1340-3451
ISSN-L : 1340-3451
Kt/V overestimates hemodialysis dose in female or smaller patients compared with that in male or larger ones : analysis by bioimpedance spectroscopy
Nana SukedaRiko KitayamaHirohisa KoteraYuko YanaiNoriyuki IeharaMasatomo Yashiro
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2015 Volume 48 Issue 9 Pages 515-523

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Abstract
【Objective】Some reports have claimed that Kt/BSA, which is Kt standardized with body surface area (BSA), is a better marker for hemodialysis (HD) dose than Kt/V. According to a study by Spalding, which used Watson’s V as total body water, Kt/V overestimated HD dose in female or smaller male patients compared with that in larger male patients, if Kt/BSA was regarded as the reference marker of HD dose, because V/BSA was less in female and smaller male patients than in larger male ones. In this study, we investigated whether the same result would be obtained in Japanese HD patients when total body water (V) actually measured by bioimpedance spectroscopy (BIS) was used. 【Method】V was actually measured in 132 maintenance HD patients after treatment. Excess fluid was calculated and V was corrected with the excess fluid (cV). 【Results】When cV was used as V, V/BSA, which is a conversion factor from Kt/V to Kt/BSA, was significantly lower in female patients than in male ones. When V/BSA was compared among four groups classified by gender and physique according to cV, V/BSA was significantly lower in female or smaller patients. 【Conclusion】Kt/V was indicated to overestimate HD dose in smaller or female Japanese HD patients compared with that in larger male ones, from a study in which V was actually measured by BIS.
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© 2015 The Japanese Society for Dialysis Therapy
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