Primary disease, age, and outcomes of 70 patients who were started on peritoneal dialysis at our center

Abstract

We evaluated the primary disease, age at the initiation of peritoneal dialysis (PD), and outcomes of 70 patients who were started on PD at our center. The major primary diseases were congenital abnormalities of the kidneys and urinary tract (38.6%), Denys-Drash syndrome (12.9%), congenital nephrotic syndrome (10.0%), juvenile nephronophthisis (5.7%), and polycystic kidney disease (5.7%). However, focal segmental glomerulosclerosis (FSGS) was only seen in one patient (1.4%). The frequencies of Denys-Drash syndrome, congenital nephrotic syndrome, and juvenile nephronophthisis were increasing. In total, 41.4% of patients were <1 year old when they started on PD. After 2008, 54.2% of patients were <1 year old when they started on PD. Regarding outcomes, 34.3% underwent kidney transplantation, 31.4% continued with PD, and 9 (13%) died. The tendency towards a younger age at the initiation of PD might have been caused a reduction in the number of older patients due to increases in the frequency of preemptive transplantation and the numbers of patients with Denys-Drash syndrome and congenital nephrotic syndrome. FSGS was not a major cause of childhood end-stage kidney disease. This study’s results might have been influenced by center bias; therefore, we need to evaluate these issues using a nationwide registry.