2026 Volume 59 Issue 2 Pages 60-63
A 58-year-old female patient was started on hemodialysis 7 years ago due to chronic kidney disease caused by nephrosclerosis. She has been undergoing maintenance dialysis three times a week since that time. Routine examination revealed a decrease in the serum magnesium level to 1.2 mg/dL. Also, she had been receiving clopidogrel and esomeprazole for the secondary prevention of cerebral infarction. Suspecting hypomagnesemia due to esomeprazole, we discontinued it, but a periodic blood draw 21 days later showed improvement, with a magnesium level of 2.2 mg/dL. It is considered that proton pump inhibitors (PPIs) can cause hypomagnesemia by inhibiting absorption from the bowel. Dialysis patients are often administered antiplatelet agents and PPIs due to the high incidence of cardiovascular disorders. Therefore, regular examination of magnesium levels in patients taking PPIs is highly recommended.
