Abstract
This report describes a successful application of hemoperfusion through charcoal in treatment of bromvalerylurea (BVU) poisoning. There are very few reports to record the blood toxin level in patient with BVU intoxication. The authors recorded the serum concentration of BVU in the patient, and studied how much the serum concentration of BVU decreased during hemoperfusion by using BVU toxic dogs.
In the case of BVU intoxication, hemoperfusion and hemodialysis were applied, Serum concentration of BVU was measured by high performance liquid chromatography, In experimental study, hemoperfusion was carried out by single-needle method inserting Shaldon catheter into femoral vein of adult dogs. The perfusion circuit had a priming volume of about 200ml saline containing 10units of heparin per ml, Blood flow-rate was maintained at 60ml/min. Blood samples were obtained before, during and after hemoperfusion for analysis of BVU.
In the case of hypnotic intoxication (BVU 11g, Diphenhydraminihydrochloridum 200mg, Phenacetin 2.7g, Caffeine 0.45g, etc. p.c.), The serum concentration of BVU decreased from 200μg/ml to 90μg/ml by hemoperfusion, In the experimental case without hemoperfusion, serum concentration of BVU in dogs showed the peak level at the fourth hr after oral administration and gradually decreased during 24hrs. In the experimental case with hemoperfusion, serum concentration of BVU in dogs decreased dramatically during hemoperfusion.
The authors propose that the charcoal hemoperfusion is dramatically effective in case of BVU intoxication, and has advantages over hemodialysis.
