Abstract
In order to investigate the pathogenesis of anemia in hemodialysis patients, various hydrolytic enzyme activities were measured in serum of 37 patients as well as of 18 control subjects. These activities were related to other clinical parameters and were analyzed with multivariate statistical methods. The results demonstrated the importance of neutral RNase, Tryptophan-aminopeptidase, BUN as accelerating factors of anemia. On the contrary, serum creatinine level, total serum protein concentration and cathepsin C were important inhibitory factors of anemia, suggesting that they are nutritional parameters of the hemodialysis patients. These metabolic factors, as a whole, proposed 60% statistical contribution in pathogenesis of anemia on the condition of the present study.
