Abstract
There are many kinds of anti-hypertensive drugs for the treatment of hypertension in chronic renal failure patients. In the treatment of patients treated by hemodialysis, it is necessary to know the accumulation, removal ratio and dialysance of these drugs.
The purpose of this study was to determine the removal rate and dialysance of Nicardipine HCl, a new calcium antagonistic vasodilator, by hemodialysis in vitro.
In this experiment, beef blood was used instead of human blood. The removal ratio and the dialysance of the drug were mesured by using this experimental circiut.
The removal ratio of the drug was 15.8±1.8% at 120 minutes after begining of hemodialysis, and the dialysance of the drug was 4.5±1.3ml/min. The half-life period of this agent was 456±81 minutes. The results show that Nicardipine HCl was slightly removed by hemodialyzer.
Two patients with hypertension who were on long-term maintenance hemodialysis were given 40-60mg of this agent orally every day. Fourteen days after the begining of drug administration, the concentration of the drug in the blood of these two patients was measured before their hemodialysis treatment. The results show that the agent does not accumulate in the blood and that the level of the drug in the blood was little changed by homodialysis treatment.
