Abstract
Acute myoglobinuric renal failure developed in two patients after they had received haloperidol. Case 1. A 55-year-old man was hospitalized in August, 1978 for involutional psychosis. On November 1, the patient began receiving haloperidol. This therapy was terminated on December 3 because of malignant syndrome. On December 10, he was admitted to Yokohama City University Hospital and underwent nine sessions of hemodialysis for acute oliguric renal failure. On admission, extreme elevations of CPK and LDH were noted, and urine and blood samples were both positive for myoglobin. Renal function improved after a month. Case 2. A 42-year-old man with a history of chorea began receiving anticonvulsants and haloperidol in 1980. In January 1982, this treatment was discontinued. Extreme involuntary movement appeared. On February 17, he received 5mg of haloperidol by muscle injection. Starting on February 20, he underwent peritoneal dialysis for acute oliguric renal failure and was admitted to Yokohama City University Hospital for hemodialysis on Feburuary 25. Extreme elevations of CPK and LDH were noted, and the blood sample was positive for myoglobin. Renal function subsequently improved. Acute renal failure may be due to rhabdomyolisis, and the relationship between haloperidol and myoglobinuria was mentioned.
