Abstract
The plasma level of ADH was measured by radioimmunoassay in 10 control subjects, and in 14 undialyzed and 18 dialyzed patients with chronic renal failure. The level of ADH was significantly higher in patients with chronic renal failure than in control subjects, and significantly higher in dialyzed than in undialyzed patients.
In undialyzed patients, significant positive correlations were observed between plasma ADH and serum creatinine, and between plasma ADH and effective plasma osmolality. A significant negative correlation was also demonstrated between plasma ADH and serum Ca.
In dialyzed patients, plasma ADH levels before hemodialysis were significantly higher than after dialysis. A significant positive correlation was observed between plasma ADH and effective plasma osmolality before and after hemodialysis. There were no correlations between plasma ADH and serum Ca, between plasma ADH and PRA, between plasma ADH and MBP, and between the change in plasma ADH and in body weight before and after hemodialysis.
These findings indicate that the secretion of ADH may be primarily regulated by the effective plasma osmolality, and that the turnover of ADH may be decreased in patients with chronic renal failure.
