Abstract
This paper discusses the lactate kinetics in CAPD. Four rate constants, lactate metabolic and peritoneal transfer rate constants KL and KLD, and the corresponding bicarbonate constants KH and KHD, were obtained for each patient by computer simulation with a compartment model.
There were no correlations between the rate constants. Also there was poor correlation between each rate constant and the patient's body weight. In particular KH values differed among the patients at a maximum of about three fold. Therefore, the optimum lactate concentration in the dialysate should be determined for each patient.
How to determine the concentration from the patient's own rate constants was established.
