Abstract
We studied low-volume dialysates in hemodialysis.Hemodialysis with a dialysate flow rate of QD 300ml/min was tried for a long period (the longest 38 weeks) in 24 cases.In the group using a large-square dialyzer BUN as well as creatinine was increased after 2 months adjusting the volume flow. However, serum creatinine was elevated at 3 months after that.In the group using standard and small-square dialyzers BUN and creatinine were not elevated before dialysis.Serum, Ca, and P did not change.Anemia did not progress.There were significant correlations between the concentration of serum solute and that in the dialysate removed by dialysis the amount of solute in the dialysate was measured after removal by dialysis, QD 500ml/min and 300 ml/min, respectively. The removal ability was higher at a flow rate of QD 500ml/min. By using four kinds of dialyzers we measured the clearance in the case of flow rates of QD 500ml/min, 400ml/min and 300ml/min in arterial pulse and constant flow. In spite of using different QD velocity rates and various kinds of dialyzes no differences in the clearances were found.We suggest that a low-dialysate flow of QD 300ml/min in both pulse flow and constant flow is possible in practice.
