Abstract
Changes of plasma Apo A1, A2, and E, HDL-ch and LCAT activity and serum cholesterol binding reserve (SCBR) were determined during a sigle hemodialysis treatment in uremics with and without complications. Plasma levels of Apo A1 and A2 decreased in hemodialyzed patients. In uremics without complications, plasma Apo A1 and A2 increased after a single hemodialysis treatment. In addition, the value corrected by serum protein concentration still showed an increase in Apo A1 and A2.
In uremics with diabetes mellitus and liver cirrhosis, no significant changes were observed in Apo A1 or A2 during a single hemodialysis.
The correlations between Apo A1 and A2, HDL-ch, LCAT activity, SCBR examined respectively during a single treatment of hemodialysis. A positive correlation was observed, especially significantly positive between Apo A1 and A2 and HDL-ch (r=0.833, r=0.641).
Changes of Apo E were not so marked after a single hemodialysis treatment, but decreased significantly in the value corrected by serum protein concentration.
Furthermore, heparin loading was carried out to examine the effect of heparin on Apo A1, A2 and E, SCBR, and HDL-ch in uremics, but no significant changes were observed.
From the above results, it was concluded that the improvement of Apo A1, and A2, HDL-ch in the four after a single treatment of hemodialysis resulted to a great extent from uremic toxins during hemodialysis.
