Manganese and nickel in chronic hemodialysis patients

Abstract

Manganese (Mn) and nickel (Ni) are essential trace elements for human nutrition. Abnormalites of Mn and Ni cause various complications in hemodialysis patients. Forty chronic hemodialysis patients and 40 healthy volunteers underwent measurements of serum and corpuscular Mn and Ni values. The relationsip between serum and corpuncular Mn and Ni levels, and RBC, Hb values and Hct values were examined and the movements of Mn and Ni during dialysis were studied. The serum Mn levels of our patients were 0.20±0.04μg/dl (normal values: 1.0±0.2μg/dl), significantly low. However corpuscular Mn values were 2.2±0.2μg/dl (normal values: 1.8+0.4) significantly high. The serum Ni levels of our patients were 0.26±0.04μg/dl (normal values: 0.52±0.10μg/dl), significantly low, but corpuscular Ni leves were 1.24±0.16μg/dl (normal values: 0.88±0.06μg/dl), signifcantly high. We did not find a significant difference of serum Mn and Ni levels between before and after dialysis. There were no significant differences of corpuscular Mn and Ni levels between before and after dialysis.
We found a significant positive relationship between serum Mn and Ni levels, and RBC, Hb values and Hct levels. There were significant negative correlations between corpuscular Mn and Ni levels, and RBC, Hb levels and Hct values.