Abstract
In 71 patients on regular hemodialysis, the serum concentration of aluminium (Al), the variation in serum concentration of Al after Desferrioxamine (DFO) loading (ΔAl), and erythrocyte Al (RBC-Al) were measured and Al accumulation was evaluated.
ΔAl at 15mg/kg of DFO indicatad a significant positive correlation with the duration of hemodialysis (r=0.51), and a remarkably higher value of ΔAl more than 150μg/l, was recognized in 12 of 15 cases with an HD history of more than 108 months.
In addition, although ΔAl at 7.5mg/kg of DFO showed a clear correlation with the ΔAl at 15mg/kg of DFO, only one of 14 cases showed ΔAl at 7.5mg/kg of DFO higher than 150μg/l.
On the other hand, neither the serum concentration of Al nor RBC-Al was correlated with the duration of hemodialysis.
We concluded that, in evaluating Al accumulation in long-term HD patients, estimation of ΔAl at 15mg/kg DFO seems to be the best method.
