1989 Volume 22 Issue 11 Pages 1201-1206
Plasmaα-ANP (atrial natriuretic peptide) was determined in 26 chronic hemodialysis patients on two consecutive occasions, on inter-dialysis as well as dialysis days, and date were analyzed in relation to weight gain from estimated dry weight, mean arterial pressure (MAP) and plasma renin activity (PRA), and its effect on the control of blood pressure was investigated.
In cases with weight gain of more than 3% of dry weight, plasmaα-ANP revealed a significant increase that was correlated with % weight gain (r=0.662, p<0.001).
On the other hand, no suppression of MAP by α-ANP was seen in patients with PRA higher 2.5ng/ml/hr or less than 2.5ng/ml/hr.
Therefore, we concluded that although plasmaα-ANP increased significantly in HD patients accordind to % weight gain, it exerted no physiologic effect on the regulation of blood pressure.
