Abstract
Low phosphate diets for the treatment of hyperphosphatemia in patients on chronic hemodialysis have been drawing attention. We investigated the effect of low phosphate milk. In 32 patients on hemodialysis, 100ml of low phosphate milk (LPK®) dissolved in 20g warm water were given once a day for one month to observe changes in Ca and P values before and after administration. For comparison the same quantity, 100ml of milk available on the market (control milk) was administered in 5 of them and changes in Ca and P values were compared 2 hours after administration.
The mean values of serum phosphate before and 4 weeks after administration of low phosphate milk in 32 patients were 6.7±1.1mg/dl and 5.5±1.2mg/dl, the latter being a significantly low value (p<0.005). Similarly, the [Ca×P] levels were 65.6±14.3 (before) and 53.2±12.2 (after), with the latter significantly lower (p<0.005). However, in 8 patients who had less than 6mg/dl of serum phosphate at the start of administration, no significant difference was noted. In the 5 patients who were given control milk, the mean value of 4.6+0.6mg/dl (before) increased to 5.1±0.6mg/dl (2 hours later), while the mean values with low phosphate milk were 4.9±0.3mg/dl (before) and 4.7±0.5mg/dl (2 hours later), exhibiting no appreciable difference.
These findings suggest that low phosphate milk is ureful in lowering the serum phosphate level and normalizing tce [Ca×P] level against hyperphosphatemia in patients on chronic hemodialysis.
