Abstract
We have reported that long-term administration of calcitonin (CT, elcatonin, ECT) to hemodialysis patients (HD-Pt) is effective in improving bone formation. However, at that time, the relation between variations in endogenous CT and the administration of CT to HD-Pt had not been clarified. This time, we measured plasma CT to study the relation between its variation and ECT administration.
The plasma CT value of 12 cases at the beginning of long-term ECT administration (6 years) was 98.9±31.2pg/ml, This decreased in 8 cases (49.6±11.1), remained the same in 3 and increased in 1, generally showing a decreasing tendency. C-PTH was observed to show a significantly positive correlation between the duration of dialysis and the ALP value, while plasma CT showed no such correlation nor any difference in group studies of high and low ALP values and diabetes VS non-diabetes.
ECT administration can be considered effective as it is thought to inhibit the progression of bone disease of HD-Pt from making progress. Although the production of ECT antibody was not observed even after 6 years of continuous ECT administration, tendency for plasma CT of decrease, suggests a the possibile inhibition of endogenous CT secretion.
