Abstract
Autosomal dominant polycystic kidney disease (ADPKD) often complicates diverticulitis in the colon in hemodialysis patients.
Barium enema study was performed in eleven hemodialysis patients (three males and eight females, 55.0±3.7% years old, duration of hemodialysis 6.5±4.9 years) (mean±S. D.) and five patients with chronic renal failure with conservative therapy (three males and two females, 51.6±8.6 years old, duration of hemodialysis 3.2±2.0 years) (mean±S. D.) due to ADPKD.
Barium enema was performed in the morning in the hemodialysis patients, most of whom were anuric, with correction afterwards for the influence of hemodialysis on the examination procedure. No accidents occurred in the barium enema study of hemodialysis patients. Of 16 patients examined, 9 (56%) had colonic diverticulosis. The existence of colonic diverticulosis in ADPKD had no relationship to the sex or age of the patient, or to the duration of hemodialysis.
Several patients had colonic diverticules in more than one part of the colon.
The frequency of patients with diverticule in each part of the colon was as follows 8 (87%) in the ascending colon, 2 (22%) in the transverse colon, O in the descending colon and 2 (22%) in the sigmoid colon. Dolichocolon was found in 5 (31%) of 16 patients examined. The existence of diverticle in the colon did not correlate with dolichocolon.
ADPKD should be recognized as a multiple malformation syndrome, having cerebrovascular abnormality, colonic diverticulosis, cardiovascular abnormality, etc. As ADPKD, which is thought to be linked to the short arm of chromosome 16, is not preventable, it is important to avoid severe complications in hemodialysis patient due to ADPKD. Thus, a good understanding of the extent and depth of the disease is required.
