Response of plasma ADH and α-hANP to changes in extracellular volume and/or plasma osmolality in patients on maintenance hemodialysis

Abstract

The effect of changes in extracellular volume and plasma osmolality on ADH and α-hANP (ANP) release was studied in 10 patients on maintenance hemodialysis. On the day of the study, the patients were treated by a one-hour ECUM followed by a 4-hour conventional hemodialysis session. The following results were obtained.
1) Initial plasma ADH and ANP levels of these patients with maintenance hemodialysis were clearly more elevated when compared with levels obtained in normally hydrated healthy volunteers.
2) The plasma ADH level remained unchanged during ECUM, but fell during hemodialysis. There were no statistically significant correlations between the change in plasma ADH level and those plasma osmolarity and extracellular fluid volume.
3) Plasma ANP level fell significantly after ECUM. There was a statistically significant correlation between the change in plasma ANP level end that in mean blood pressure.