Abstract
To evaluate the eflects of improvement in renal anemia on cerebral blood flow, six patients on initial hemodialysis therapy were studied before and after improvement of their anemia using recombinant human erythropoietin (rHuEPO). In five of the six patients the hematocrit increased more than 28%, while in one patient it remained under 23%.
Cerebral blood flow was measured by single photon emission computer tomography using 131I-IMP. The results were as follows. Anterion cerebral blood flow decreased from 84.61±21.91 (ml/100g/min) to 75.74±20.28, posterior cerebral blood flow from 98.42±24.52 to 86.34±23.69 (p<0.05), and whole cerebral blood flow from 91.53±24.53 to 81.05±21.55 (p<0.05).
These results indicated that cerebral blood flow increased by anemia can be improved by the use of rHuEPO.
