Abstract
A 30-year-old man was treated with HDF, using 4L of displacement liquid and a polysulfone membrane dialyser (F60), for 4 hours every day because of MOF. MRSA, being responsive only to VCM, was detected by blood culture. Therefore, 500mg VCM dissolved in 250ml, a 5% glucose solution, was applied by drip infusion for 1 to 1.5 hours after HDF, every other day for one month. Blood concentrations of VCM were measured before each HDF.
The average VCM blood concentration was 25.5±4.3 on the first day and 16.8±2.7μg/ml on the second day. Deposition of VCM in blood was not detected, despite long-term administration. Blood concentrations of VCM decreased gradually after discontinuance and had fallen to 3.2μg/ml by the 7th day. No side effects of VCM occurred during the observation period.
