Abstract
Many issues remain to be clarified with regard to the peritoneal dialysis of amino acid in CAPD cases. In this study, neutral amino acids in the blood and excreta, particularly the Fischer ratio, were investigated. The subjects were 15 patients (14 males and 1 female, mean age: 49±9 years) consisting of 6 cases of diabetic renal insufficiency (DM) and 9 cases of non-diabetic renal insufficiency who had beed managed on an outpatient basis and had never had peritonitis. Two liters of 2.5% Dianeal® was infused into the peritoneal cavity and retained intraperitoneally for exactly 4 hours from the end of infusion to the beginning of drainage. Amino acids in the blood and excreta were measured and the Fischer ratio (Val+Leu+Ile/Phe+Tyr) was calculated.
1) There was an excellent correlation between the molecular weight (log MW) of neutral amino acids and the mean D/P ratio in the 15 CAPD cases (Y=1-0.137X, R=-0.986). 2) The Fischer ratio was 2.72 in the blood and 3.09 in the excreta, thus showing a higher value in the excreta (p<0.001). 3) There was no significant Fischer ratio correlation in the blood and excreta between diabetic and non-diabetic cases.
Based on the above results, in CAPD cases, the D/P ratio of neutral amino acids is in sequence with molecular weight and the Fischer ratio of amino acids is significantly higher in excreta than in blood.
