Abstract
A 38-year-old female patient, who had been undergoing maintenance hemodialysis therapy since March 1987 because of chronic renal failure due to IgA nephropathy, is presented. She had gradually developed difficulty in walking since two years after starting hemodialysis therapy, and was diagnosed as having limb-girdle myodystrophy on examination.
Her course was complicated by myoglobulinemia because myoglobulin was produced in large quantities due to rhabdomyolysis associated with limb-girdle myodystrophy and urinary myoglobulin excretion was decreased due to chronic renal failure associated with IgA nephropathy.
After blood purification was changed from hemodialysis (HD) to hemodiafiltration (HDF) and membrane of dialysis was changed for improvement of myoglobulinemia, the concentrations of myoglobin in her blood and urine decreased, urine volume increased and uremia improved slightly. Then, the blood purification frequency was decreased from three times to twice a week. We speculate that urine volume increased because renal tubule damage by myoglobulinemia was reduced with the introduction of membrane and hemodiafiltration.
