Analysis of low serum activities of GOT and GPT in hemodialysis patients by eliminating confounding factors

Abstract

Serum activities of GOT, GPT and γ-GTP were statistically analyzed in 157 healthy controls and 117 patients with chronic renal failure undergoing hemodialysis. Subjects with abnormally elevated values of these enzyme activities were excluded. GOT and GPT activities in hemodialysis patients with negative HBs antigens and HCV antibodies were significantly lower than those in healthy controls, although γ-GTP activities did not differ between the two groups. Identical results were obtained by analysis of age-matched or body mass indexmatched data of the two groups. On the basis of these results, 21IU/l of GOT and 18IU/l of GPT are suggested as practical cut off levels for hemodialysis patients.