Nihon Toseki Igakkai Zasshi
Online ISSN : 1883-082X
Print ISSN : 1340-3451
ISSN-L : 1340-3451
A study of erythrocyte ferritin content (RBC-Ft) in hemodialysis patients
variation of RBC-Ft after rHuEPO therapy
Nobuo OyamaMari MasudaMasayo NodaYoshihiro MotomiyaEigoro Okajima
Author information
JOURNAL FREE ACCESS

1995 Volume 28 Issue 8 Pages 1111-1117

Details
Abstract
In rHuEPO therapy for renal anemia, assessment of systemic iron deficiency is essential for maintaining clinical efficacy and determination of optimal rHuEPO dosing.
The serum ferritin level (S-Ft) has been widely acknowledged to be an indicator of bodily iron stores, but it is currently being proposed that measurement of the erythrocyte ferritin content (RBC-Ft) is more valuable and a more accurate real-time marker, of functional iron storage, in some hematological diseases.
In this study, we measured RBC-Ft in 16 normal subjects (controls) and 47 patients on maintenance hemodialysis. The mean value for RBC-Ft was 25.0±16.6ag/cell in patients and 25.6±17.3ag/cell in healthy controls. Although S-Ft and RBC-Ft failed to correlate significantly with the serum iron (S-Fe) value, a significant correlation between increased hemoglobin and variations in RBC-Ft, after rHuEPO therapy, was recognized (r=0.461, p<0.05).
Based on these results, we conclude that measurement of RBC-Ft could be of value in assessing functional systemic iron stores in maintenance hemodialysis patients, who comprise the vast majority of candidates for rHuEPO therapy.
Content from these authors
© The Japanese Society for Dialysis Therapy
Previous article Next article
feedback
Top