Abstract
The efficacy of Lidocaine-containing local analgesic patch (tape-typed), Penles® and the optimum conditions for use were investigated in 17 patients receiving chronic hemodialytic treatment (14 males and 3 females). The degree of pain at the puncture of blood access was evaluated using the visual analogue scale (VAS). The degree of pain was compared among the subject groups to whom a patch was applied for 30, 60 and 90 min before puncture (group 30, group 60 and group 90). A control group received the puncture without the application of a patch. The mean VAS scores (mean±S. E.) of group 30, group 60 and group 90 were 4.57±0.72, 3.00±0.51 and 2.69±0.48, respectively, and was 9.82±1.24 for the control group. There were significant differences between group 30 and the control, and group 60 and group 90 (p<0.001). In addition, the difference between group 30 and group 90 was significant (p=0.015). There was no significant difference between group 30 and group 60 (p=0.051) and between group 60 and group 90 (p=0.329). These results show that the preparation Penles® is effective in decreasing the pain due to puncture. Although the differences between the VAS levels of group 30 and group 60 were not statistically significant, the value showed a decreasing tendency (p=0.051). Thus, the optimum application time of this patch was considered to be longer than 60min. However, it is difficult to uniformly determine the optimum conditions because individual differences in the optimum application time were fairly large.
Therefore, the optimum time for the use of these patches should be chosen in each case by testing various times of application.
