Abstract
A 79-year-old man with chronic renal failure secondary to nephrosclerosis, who had been on maintenance hemodialysis for 54 months, was evaluated because of a prostatic nodule palpated on a screening digital rectal examination. Histopathological examination of the biopsy specimens taken from the right lobe of the prostate disclosed moderately to poorly differentiated adenocarcinoma of the prostate.
Antiandrogen therapy was begun with 3.75mg of LH-RH agonist (leuprorelin acetate) subcutaneously every four weeks and 100mg of chlormadinone acetate (CMA) orally per day, under a diagnosis of stage B1 carcinoma of the prostate.
The serum prostate specific antigen (PSA) level before treatment was elevated to 13.8ng/ml (normal<3), but normalized within two months of initiating therapy. After 8 months of treatment with LH-RH agonists and CMA, the serum PSA remained at this level.
Prostatic cancer has an increased incidence in aged men. Because of the increasing aged population, prostatic cancer in elderly patients on hemodialysis should be carefully considered.
