1996 Volume 29 Issue 6 Pages 1043-1048
The effect on the rate and amount of removal of low molecular weight substances (UN, Cr, UA, iP), middle molecular weight substances (peak-2a) and low molecular proteins (β2-MG) following changes in dialysis flow, dialysis time and blood flow were examined in hemodialysis patients. In addition the effect on the KT/V of urea and TACBUN by changes in blood flow was examined. The removal rate of all substances studied did not differ between a 500ml/min rate of dialysate flow and a 400ml/min rate of dialysate-flow, nor between four or five hour hemodialysis. The total removal amounts of all substances tested for, at a dialysate flow of 500ml/min over a five hour hemodialysis period were higher than at a dialysate flow of 400ml/min over a four hour period of hemodialysis.
The KT/V of urea and TACBUN at a blood-flow rate of 280ml/min were higher than at a blood flow rate of 220ml/min, but remained within normal limits.
From these results, we concluded that a rate of dialysis flow of 500ml/min was more effective than 400ml/min for the removal amount of various substances, and that five-hour-hemodialysis was more effective than hemodialysis over a four hour period for the removal amount.