A hemodialysis patient with ASO effectively treated by PGE1 via extracorporeal circulation during HD

Kaori Kanegae; Akihiko Osajima; Yujiro Watanabe; Hirofumi Anai; Kayoko Segawa; Takeshi Suda; Takayuki Ohta; Masako Iwamoto; Hiroshi Tanaka; Narutoshi Kabashima; Masahito Tamura; Tomoko Shimoike; Nobuhiro Ohnari; Yasuhide Nakashima

doi:10.4009/jsdt.34.1101

A hemodialysis patient with ASO effectively treated by PGE₁ via extracorporeal circulation during HD

Kaori Kanegae, Akihiko Osajima, Yujiro Watanabe, Hirofumi Anai, Kayoko Segawa, Takeshi Suda, Takayuki Ohta, Masako Iwamoto, Hiroshi Tanaka, Narutoshi Kabashima, Masahito Tamura, Tomoko Shimoike, Nobuhiro Ohnari, Yasuhide Nakashima

Author information

Kaori Kanegae
Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine
Akihiko Osajima
Kidney Center, University of Occupational and Environmental Health, School of Medicine
Yujiro Watanabe
Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine
Hirofumi Anai
Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine
Kayoko Segawa
Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine
Takeshi Suda
Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine
Takayuki Ohta
Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine
Masako Iwamoto
Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine
Hiroshi Tanaka
Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine
Narutoshi Kabashima
Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine
Masahito Tamura
Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine
Tomoko Shimoike
Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine
Nobuhiro Ohnari
Department of Radiology, University of Occupational and Environmental Health, School of Medicine
Yasuhide Nakashima
Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine

Keywords: ASO, PGE₁

JOURNAL FREE ACCESS

2001 Volume 34 Issue 6 Pages 1101-1105

DOI https://doi.org/10.4009/jsdt.34.1101

Details

Abstract

Prostaglandin E₁ (PGE₁) is known to improve the impaired microcirculation due to peripheral arterial occlusive disease. We report a hemodialysis (HD) patient with arteriosclerosis obliterans (ASO) treated by intravenous PGE₁ administration during HD.
A 71-year old man with a history of chronic renal failure and bilateral femoral-popliteal artery bypass surgery for ASO was admitted to our hospital. He presented resting pain of the right lower limb and intermittent claudicatin.
After admission, his renal function was gradually deteriorated and began receiving HD treatment. IADSA revealed stenosis of the right common iliac artery proximal to the previous bypass graft. We performed intraarterial metallic stenting and slowly administrated PGE₁ via extracorporeal circulation during HD. One month later (after 14 therapy sessions), he felt no resting pain in the limbs and the pain-free walking distance was increased.
The present case suggests that i. v. PGE₁ administration during HD could be a useful treatment in managing HD patients with ASO.

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