Nihon Toseki Igakkai Zasshi
Online ISSN : 1883-082X
Print ISSN : 1340-3451
ISSN-L : 1340-3451
Longitudinal changes in dialysate CA125 levels in peritoneal dialysis patients
Tomonari OkadaToshiyuki NakaoHiroshi MatsumotoHiromi HidakaMaki YoshinoTamami ShinoYume NagaokaFumihiro TakeguchiHideaki IwasawaRyo TomaruToshikazu Wada
Author information
Keywords: CA125
JOURNAL FREE ACCESS

2003 Volume 36 Issue 10 Pages 1545-1552

Details
Abstract
Previous studies suggested that cancer antigen 125 levels (dCA125) in peritoneal dialysate could be a marker of mesothelial cell mass in stable peritoneal dialysis (PD) patients. We evaluated longitudinal changes of dCA125 in a total of 70 PD patients. The duration of observation was 34±15 months. Every 6 months, dCA125 was determined from effluents during a 4-hour dwell using 2.5% glucose dialysates. There was no relationship with the duration of PD and no significant changes in dCA125 over 3 years were found in 21 patients who had just started PD or in 11 patients whose duration of PD was 5 years or longer. A significant decrease in dCA125 was demonstrated after peritonitis episodes in 26 patients (23.2±12.1→9 months later 14.4±8.4U/mL, p<0.05). In 6 patients who developed encapsulating peritoneal sclerosis after discontinuation of PD, dCA125 significantly decreased in the final 2 years of PD (21.7±8.8→9.0±4.6U/mL, p<0.05). These results suggest that dCA125 remains longitudinally stable in PD patients. A decrease in dCA125 was found in some PD patients with peritonitis episodes or development of peritoneal sclerosis. However, interindividual variability exists and it is difficult to find significant changes in dCA125 associated with these clinical outcomes in PD patients.
Content from these authors
© The Japanese Society for Dialysis Therapy
Previous article Next article
feedback
Top