Abstract
Amantadine hydrochloride is not only widely used to treat Parkinson's disease, it has also been heralded in recent years as effective for treating influenza. However, given the fact that amantadine hydrochloride is eliminated by the kidneys and not dialysable, practitioners should pay attention to this medication for patients with renal failure. We have recently experienced a case of amantadine hydrochloride intoxication in a dialysis patient who demonstrated Parkinson's symptoms. The case was an 82-year-old male who was prescribed 150mg/day of amantadine hydrochloride after exhibiting exacerbated articulation disorder, festination and frozen gait. The patient subsequently presented involuntary movement, uneasiness and delirium and was diagnosed with amantadine hydrochloride intoxication. We performed DHP and HF to eliminate the causative agent and the patient recovered completely. DHP exhibited effective removal capacity, with a 93.5% adsorption rate. While there are no reports of eliminating amantadine hydrochloride by using HF, this technique exhibited a removal rate of 23.5%, suggesting its possible efficacy.
