Abstract
Light chain deposition disease (LCDD) is a relatively rare condition. It is characterized by multiple organ dysfunction caused by the deposition of light chain protein, production of which is monoclonally increased. We describe a patient with LCDD without multiple myeloma. A 44-year-old woman was admitted to our hospital with rapidly progressive renal dysfunction and anemia. Serum and urine analysis demonstrated monoclonal κ light chain of immunoglobulin G. Immunofluorescence micrography demonstrated κ light chain in the glomerular capillary loops, Bowman's capsules, tubular basement membranes and small vessels. The patient was treated with two courses of melphalan combined with prednisolone soon after the onset of LCDD. After chemotherapy, serum levels of immunoglobulin G and monoclonal protein decreased and further progression renal dysfunction did not seem to develop. However, the patient refused to accept any further immunosuppressive therapy. Two years later, renal dysfunction progressed to end stage renal disease. There after, she was treated by maintenance hemodialysis. Immunosuppressive therapy may effectively prevent renal deterioration during the early phase soon after LCDD onset. Renal function might be preserved for a long time in patients with LCDD by continuing long-term intermittent chemotherapy.
