Abstract
Adiponectin (ADPN) is a secretory protein from adipose tissue. A plasma ADPN level has been reported to be reduced in patients with atherosclerotic complications. We investigated plasma ADPN levels in patients on peritoneal dialysis to test its predictive power for cardiovascular events.
We measured plasma levels of ADPN, leptin, tumor necrosis factor (TNF)-α, plasminogen activator inhibitor type 1 (PAI-1) in 29 patients on peritoneal dialysis. Plasma ADPN levels were higher in patients on peritoneal dialysis (27.7±17.8, μg/mL) than in healthy subjects.
The plasma ADPN level was inversely related to the plasma leptin level (r=-0.58), %body fat (r=-0.43), homeostasis model assessment (HOMA-R) (r=-0.54), visceral fat area (VFA) (r=-0.50) and aortic calcification index (ACI) (r=-0.40). However, the level of ADPN was not correlated to that of TNF-α or PAI-1 in plasma.
These results indicate that the plasma ADPN level is inversely related to metabolic risk factors, and can be a predictor of cardiovascular outcomes in patients on peritoneal dialysis.
