Change in trans-lymphatic fluid absorption, evaluated by ^99mTc-HSAD, in a CAPD patient after tranexamic acid administration

Abstract

A 70-year-old male patient who had been on hemodialysis due to idiopathic kidney disease was transferred to continuous ambulatory peritoneal dialysis (CAPD) because of hypotension during hemodialysis sessions.
Immediately following the start of CAPD, he developed ultra-filtration failure (UFF). Peritoneal equilibration test demonstrated a high transport peritoneum (D/P Cr=0.81). Measurement of lymphatic absorption using ^99mTc-HSAD showed a lymphatic absorption of 343mL/4h. After administration of tranexamic acid, UFF was dramatically reduced and lymphatic absorption decreased markedly. However, there was no change in the high transport peritoneum (D/P Cr=0.89). We conclude that tranexamic acid administration improves UFF in CAPD patients through inhibition of lymphatic absorption.