Abstract
We used vitamin E-coated membranes to treat of chronic haemodialysis patients, examining the effects during dialysis (Protocol 1) and those of long-term use for 3 years (Protocol 2), and studied changes in lipid peroxide (oxidized LDL, MDA-LDL) in plasma. During dialysis, the vitamin E-coated membrane significantly reduced changes in oxidized LDL compared to those using polysulfone membrane and regenerated cellulose membrane (7 patients for each group). In the examination of long-term use for 3 years (11 chronic dialysis patients), oxidized LDL and MDA-LDL were both reduced. In comparison between DM (patients with diabetic mellitus) and Non-DM groups, there was no significant difference. Vitamin E-coated membranes might suppress the development of arterial sclerosis in dialysis patients, because it was shown that vitamin E-coated membranes lowered lipid peroxide levels in blood both during dialysis and in long-term use.
