Abstract
Correct use of carbapenem broad band antibiotics was promoted among clinical pharmacists in cooperation with a pharmacist specialized in infection control. Clinical pharmacists used the Antibiotics PK/PD check sheet from July, 2006 to confirm the prescription details, causative bacterial species, MIC, and kidney function, and to suggest any query of alternative prescription for the chief physician if necessary. Use of broadband penicillins, and broadband cephalosporins and carbapenems was compared before (133 examples) and after (about 470 examples) starting use of the Antibiotics PK/PD check sheet. Use of penicillin and cephalosporin dose regimens twice a day decreased from 94.7% to 75.8%, once a day increased from 3.5% to 6.6%, and three times a day increased from 1.8% to 17.2%. In addition, use of carbapenem dose regimen twice a day decreased from 94% to 73%, once a day increased from 0% to 4.9%, and three times a day increased from 6% to 21.7%. The average dosage of carbapenems increased from 1.06 g to 1.2 g per day, but the average days of use decreased from 6.76 to 6.01. The detection rate of multidrug resistant P. aeruginosa search frequency decreased significantly. Use of the Antibiotics PK/PD check sheet by clinical pharmacists was effective to promote appropriate use and dosage of antibiotics, and to suggest important queries to the chief physician.
