2008 Volume 23 Issue 3 Pages 175-180
Antibiotic-associated diarrhea (AAD) has recently become a more common cause of death. The factors causing AAD were investigated by analysis of antibiotic use and occurrence of AAD in our hospital during the past 4 years. The amount of antibiotics administered to patients who developed AAD was analyzed from 2003 to 2006. The antibiotics were classified and the usage rates analyzed. The amount of antibiotics decreased, but the number of patients who developed AAD increased in 2006. The difference in antibiotic use according to the classification of antibiotics was analyzed for 2005 and 2006. The results revealed that the usage of third and fourth generation cephems had increased. Therefore, use of these antibiotic groups may be important in the onset of AAD. The group of patients who developed AAD was compared with a control group. Use of the third and fourth generation cephem and carbapenem antibiotics was significantly higher in the AAD group. Therefore, we conclude that antibiotics with a broad antibacterial spectrum tended to cause the onset of AAD.
