Anti-microbial Effect and Skin Stimulating Response of pH 7.2 Modified Disinfectant Containing Chlorine Dioxide

Abstract

  We have developed a new disinfectant containing chlorine dioxide (600 ppm). Detailed microbiocidal studies using pathogenic bacteria have been carried out previously. This new disinfectant is an alkaline solution (pH 8.8), so stimulates the skin when used as a disinfectant. Therefore, the effects of newly neutralizing (pH 7.2) with a buffer solution were tested on the microbiocidal effects and stimulation activities of the topical solution in guinea pigs. After 5 minutes incubation, the neutralized (pH 7.2) chlorine dioxide solution (3000 ppm) killed various microbacteria (Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans, S. erratia marcescens, and MRSA). Application of a 4-times higher concentration of neutralized chlorine dioxide solution to the skin of guinea pigs for 10 continuous days caused no observed redness or swelling. Neutralized chlorine dioxide solution is a safe and odorless solution, and will be useful as a disinfectant for equipment, staff, and patients in medical institutions.